Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. endobj
More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Avicel PC 611 Microcrystalline Cellulose. : 160182 Date Approved: 05/25/2010 Revision No. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >>
Performing this action will revert the following features to their default settings: Hooray! There have always been two different points of view for the liquidity of MCC. 2008-2023 ChemPoint. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Are you sure you want to delete your template? Aqueous suspensions of microcrystalline cellulose have . Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. JFIF ` ` ZExif MM * J Q Q Q C
To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. %PDF-1.5
These grades have particle sizes ranging from <30 to approximately 200. CAS 9004-34-6. It works as a moisture sponge and permits the controlled growth of spheroids. cas:9000-11-7 msds Carboxymethyl cellulose. <> common form is used in vitamin supplements or tablets. The short-term limit for total inhalable dust is 20 mg/m3. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& . Microcrystalline Cellulose Side Effects. High performance lubricant that brings more to the tablet. We are artists at heart and creators by nature. It is available in different grades and particle sizes. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. All Rights Reserved. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. (1962). The typical mean particle size is 20200 m. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. Unique functionality for a broad range of pharmaceutical applications. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. endstream
If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. If breathing is difficult or if . Magazine: Material safety data sheet - FMC Corporation. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. endobj
Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. cas:9032-51-3 msds CELLULOSE PAB. Product Name: Microcrystalline Cellulose E460 1.2. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used.
!(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Learn about FMC's industry leading goal of net-zero emissions by 2035. Medium size standard MCC grade, suited for the majority of directly compressible actives. <<
Avicel PC 611 (FMC Biopolymer) Supplied by. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Find answers in our support articles. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. <>
%PDF-1.3 xv}O2' H~KEe9>G/,:9\i (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Terms and Conditions Compliance Solutions Industries About 3E News & Events . Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. X\o^ MATERIAL SAFETY DATA SHEET. However, consumption of large quantities of the material may have a laxative effect. We respect your privacy FMC Privacy Policy. Chemical Formula: (C6H10O5)n 1.4. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. 0.25 - 0.37. MATERIAL SAFETY DATA SHEET. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. >>
TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. >>
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Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. undefined. X]s
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With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. : 160182. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. There may be more fiber in your food than you realized. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. endobj
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3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W ChemicalBook. Earth Supplied Products LLC. Gloves, eye protection and a dust mask should be used. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. FMC Corporation. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Document(s): certificate data msds. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q
c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5
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U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Heavy metals, % NMT 0.001 Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. /MediaBox [0 0 612 792]
However, it yields non-digestible fibre. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Dyvo5bp#bR W7~IF C"
d6zLz~!#>@HO}sx;hm>> Product Name Cellulose microcrystalline. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Explore how you can develop your career and bring your creative ideas to life at IFF. CAS #: 9004-34-6 1.6. Meet our leadership team. ). The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Chemical Formula: (C6H10O5)n 1.4. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. A family of polysaccharide products that allow distinctive drug delivery solutions. ( Production of Pharmaceutical Grade Microcrystalline Cellulose. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4(
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%QL((((((((((((((((((((((((((((((((((((((((P3NhC As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. 51395-75-6 Avicel RC 591. Battista, O. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . stream It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. 1. If you are already a ChemPoint customer then sign up for access to our online ordering website. No. Quantity: 1 700 kgs. 1 0 obj
!,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Combines good flow and high compactibility. : 51395-75-6 Date Approved: 01/31/2008 Revision No. An agricultural sciences company. Your file is uploaded and ready to be published. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. SDS. Microcrystalline Cellulose E460 MSDS 1. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. . ( Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. q86@on$^X_HuH;3` MATERIAL SAFETY DATA SHEET Version: 1.0 1. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Cellulose microcrystalline. Regulatory Information stream
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/PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, %
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Cu:3(]N"AQdUt~h|P The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. q9;v80q>jZ It is also used in plaque assays for counting. Explore how we work and why we apply science and creativity for a better world to everything we do. 1.3. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Avicel Microcrystalline Cellulose Physical Properties. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Synergies to simplify formulation challenges and reduce operational costs. gwf;J(e0o|1p{R~P^);ao!%{0KD7. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Validity Area. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. By producing Avicel . stream
Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. : CL-611NF Date Approved: 01/13/2010.